A truly green synthesis of a-aminonitriles via Strecker reaction

Authors

Debasish Bandyopadhyay, The University of Texas Rio Grande ValleyFollow
Juliana M. Velazquez, The University of Texas Rio Grande Valley
Bimal K. Banik, The University of Texas Rio Grande Valley

Document Type

Article

Publication Date

10-2011

Abstract

Background: The classical Strecker reaction is one of the simplest and most economical methods for the synthesis of racemic a-aminonitriles (precursor of a-amino acids) and pharmacologically useful compounds.

Results: Indium powder in water is shown to act as a very efficient catalyst for one-pot, three-component synthesis of a-aminonitriles from diverse amines, aldehydes and TMSCN. This general rapid method is applicable to a wide range of amines and aldehydes and produces products in excellent yield.

Conclusions: The present one-pot, three-component environmentally benign procedure for the synthesis of aaminonitriles will find application in the synthesis of complex biologically active molecules.

Comments

Original published version available at doi.org/10.1186/2191-2858-1-11

Recommended Citation

Bandyopadhyay, D., Velazquez, J. M., & Banik, B. K. (2011). A truly green synthesis of α-aminonitriles via Strecker reaction. Organic and Medicinal Chemistry Letters, 1(1), 11. https://doi.org/10.1186/2191-2858-1-11

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Publication Title

Organic and Medicinal Chemistry Letters

DOI

10.1186/2191-2858-1-11