Document Type
Article
Publication Date
10-4-2011
Abstract
Polycyclic aromatic hydrocarbons (PAHs) are considered to be significant environmental carcinogens. Additionally, various planar ring systems are capable of intercalating with DNA, leading to a number of drugs that possess chemotherapeutic activity. In this study, three new polyaromatic compounds with a side chain were synthesized, and spectroscopic as well as elemental analyses were performed. The addition of the long chains to either chrysene or pyrene caused a red-shift in the spectral emission when compared to the corresponding polycyclic aromatic hydrocarbons itself. Furthermore, the cytotoxicity of the three novel polyaromatic compounds was evaluated in vitro in a panel of cultured mammalian cell lines. The pyrenyl ether demonstrated better cytotoxicity compared to cisplatin against colon (HT-29) as well as cervical (HeLa) cancer cell lines. In conclusion, three new compounds were synthesized and investigated in this study. This novel method is likely to play a role in other areas of research.
Recommended Citation
Bandyopadhyay, D., Granados, J. C., Short, J. D., & Banik, B. K. (2012). Polycyclic aromatic compounds as anticancer agents: Evaluation of synthesis and in vitro cytotoxicity. Oncology Letters, 3(1), 45–49. https://doi.org/10.3892/ol.2011.436
First Page
45
Last Page
49
Publication Title
Oncology Letters
DOI
10.3892/ol.2011.436
Comments
© 2012 Spandidos Publishing. Original published version available at http://doi.org/10.3892/ol.2011.436