Computer Science Faculty Publications

Document Type

Conference Proceeding

Publication Date

3-10-2026

Abstract

With the rapid progress of large language models (LLMs), advanced multimodal large language models (MLLMs) have demonstrated impressive zero-shot capabilities on vision–language tasks. In the biomedical domain, however, even state-of-the-art MLLMs struggle with basic Medical Decision Making (MDM) tasks. We investigate this limitation using two challenging datasets: (1) three-stage Alzheimer’s disease (AD) classification (normal, mild cognitive impairment, dementia), where category differences are visually subtle, and (2) MIMICCXR chest radiograph classification with 14 non–mutually exclusive conditions. Our empirical study shows that text-only reasoning consistently outperforms vision-only or vision–text settings, with multimodal inputs often performing worse than text alone. To mitigate this, we explore three strategies: (1) in-context learning with reason-annotated exemplars, (2) vision captioning followed by text-only inference, and (3) few-shot fine-tuning of the vision tower with classification supervision. These findings reveal that current MLLMs lack grounded visual understanding and point to promising directions for improving multimodal decision making in healthcare.

Comments

©2025 IEEE

Publication Title

2025 IEEE International Conference on Data Mining Workshops (ICDMW)

DOI

10.1109/ICDMW69685.2025.00245

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