Document Type
Article
Publication Date
Fall 8-28-2022
Abstract
Extracellular Vesicles, and more specifically, exosomes, are essential for effective cell-to-cell communication in a wide variety of tissues. In the last couple of decades, these nanovesicles have been proven to be active participants and regulators in many disease processes; therefore, their therapeutic effects have been widely studied and proven in various cardiovascular diseases both, in vitro and in vivo. Thus, this study aims at assessing the effects of running healthy mice exosomes on cardiomyocyte and cardiac tissue samples obtained from diabetic mice. Here, we successfully extract exosomes from mice plasma and detect their presence through the use of anti-CD9 and anti-CD81 antibodies. Further work includes concentrating exosome presence and utilizing a wider variety of exosome-specific antibodies, as well as exploring techniques for more effective exosome extraction from plasma.
Recommended Citation
Garza, Miguel A.; Ramírez-Correa, Genaro A.; Garza-Rodríguez, Maria Lourdes; and Medina, Andres J., "Healthy Exosomes and their Effects on Diabetic Cardiomyocytes" (2022). MEDI 9331 Scholarly Activities Clinical Years. 62.
https://scholarworks.utrgv.edu/som9331/62
Academic Level
medical student
Mentor/PI Department
Molecular Science
Included in
Biological Phenomena, Cell Phenomena, and Immunity Commons, Cardiology Commons, Circulatory and Respiratory Physiology Commons, Investigative Techniques Commons, Medical Molecular Biology Commons, Medical Pathology Commons, Medical Physiology Commons, Physiological Processes Commons