School of Medicine Publications and Presentations

Document Type

Article

Publication Date

4-3-2023

Abstract

Objectives

Glioblastoma multiforme (GBM) is a common and fatal brain tumour in the central nervous system with a poor survival rate and a median survival time of 15 months only. The standard treatment is aggressive surgical resection followed by radiotherapy and chemotherapy. However, effective drugs available in chemotherapy are limited. This study was designed to evaluate, for the first time, the potential therapeutic effect of Cissus quadrangularis (CQ) in human glioblastoma cells and to investigate its possible mechanisms of action. Methods

In this study, we examined the anticancer activity of CQ in human glioblastoma U87 MG cells by cell viability assay, cell migration assay, immunofluorescence staining and Western blot. Results

Our results demonstrated that CQ treatment induced U87 cytotoxicity, cell cycle arrest and cell death. The cytotoxicity of CQ mediates ER stress, autophagy and mitochondrial apoptosis by suppressing pro-survival signalling pathways (extracellular signal-regulated kinase and signal transducer and activator of transcription 3 pathways). Conclusions

The findings of this study imply that CQ is a promising anti-cancer candidate for the treatment of GBM. Highlights

  • The anticancer effect of Cissus quadrangularis (CQ) was studied in human glioblastoma U87 MG cells.

  • It was demonstrated that CQ treatment induced cytotoxicity, cell cycle arrest and cell death in U87 MG cells.

  • CQ may become a potential chemotherapy component for the treatment of glioblastoma multiforme.

Comments

© The Author(s) 2023

Creative Commons License

Creative Commons Attribution-NonCommercial 4.0 International License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License

Publication Title

RPS Pharmacy and Pharmacology Reports

DOI

10.1093/rpsppr/rqad014

Academic Level

faculty

Mentor/PI Department

Molecular Science

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