Optical detection of the structural properties of tumor tissue generated by xenografting of drug-sensitive and drug-resistant cancer cells using partial wave spectroscopy (PWS)

Authors

Prakash A. Adhikari
Prashanth K.B. Nagesh, The University of Texas Rio Grande Valley
Fatemah Alharthi
Subhash C. Chauhan, The University of Texas Rio Grande ValleyFollow
Meena Jaggi, The University of Texas Rio Grande Valley
Murali M. Yallapu, The University of Texas Rio Grande ValleyFollow
Prabhakar Pradhan

Document Type

Article

Publication Date

12-2019

Abstract

A mesoscopic physics-based optical imaging technique, partial wave spectroscopy (PWS), has been used for the detection of cancer by probing nanoscale structural alterations in cells/tissue. The development of drug-resistant cancer cells/tissues during chemotherapy is a major challenge in cancer treatment. In this paper, using a mouse model and PWS, the structural properties of tumor tissue grown in 3D structures by xenografting drug-resistant and drug-sensitive human prostate cancer cells having 2D structures, are studied. The results show that the 3D xenografted tissues maintain a similar hierarchy of the degree of structural disorder properties as that of the 2D original drug-sensitive and drug-resistant cells.

Comments

© 2019 Optical Society of America under the terms of the OSA Open Access Publishing Agreement. Original published version available at https://doi.org/10.1364/BOE.10.006422

Recommended Citation

Adhikari, P., Nagesh, P. K. B., Alharthi, F., Chauhan, S. C., Jaggi, M., Yallapu, M. M., & Pradhan, P. (2019). Optical detection of the structural properties of tumor tissue generated by xenografting of drug-sensitive and drug-resistant cancer cells using partial wave spectroscopy (PWS). Biomedical optics express, 10(12), 6422–6431. https://doi.org/10.1364/BOE.10.006422

First Page

6422

Last Page

6431

Publication Title

Biomedical Optics Express

DOI

10.1364/BOE.10.006422

Academic Level

faculty

Mentor/PI Department

Immunology and Microbiology