Facile synthesis of diverse N-Acyl Anthranilamides and quinazolin-4-ones as HMG-CoA reductase inhibitor via Pd-catalyzed cascade reaction

Authors

Pathan Sultan Ismail
Irfan Khan
Vivek Kumar
Ved Prakash Verma
Monika Shukla
Anupam Dhasmana, The University of Texas Rio Grande Valley
Shashi Pandey
Girdhar Pal Singh
Jaybir Singh
Shahnawaz Khan

Document Type

Article

Publication Date

2019

Abstract

This manuscript describes the design and synthesis of a series of diverse N-Acyl Anthranilamides and quinazolin-4-ones derivatives (3a-3n, and 4a-4d) inhibitors of HMG-CoA reductase for the treatment of hypercholesterolemia. A series of N-Acyl Anthranilamides and quinazolin-4-ones derivatives (3a-3n, and 4a-4d) were synthesized and their chemical structures were confirmed by 1 H, 13C NMR and mass spectral data. Analogs were optimized using structure-based design and physical property considerations resulting in the identification of 4b and 3d, a hepatoselective HMG-CoA reductase inhibitor with excellent acute and chronic efficacy in a vitro model.

Comments

© Chemistry & Biology Interface is the property of Indian Society of Chemists & Biologists. Original published version available here.

Recommended Citation

Ismail, P. S., Khan, I., Kumar, V., Verma, V. P., Shukla, M., Dhasmana, A., Pandey, S., Singh, G. P., Singh, J., & Khan, S. (2019). Facile synthesis of diverse N-Acyl Anthranilamides and quinazolin-4-ones as HMG-CoA reductase inhibitor via Pd-catalyzed cascade reaction. Chemistry & Biology Interface, 9(3), 172–185.

First Page

172

Last Page

185

Publication Title

Chemistry & Biology Interface

Academic Level

faculty

Mentor/PI Department

Immunology and Microbiology