Acquired Factor VIII Deficiency Presenting as Gross Hematuria in a Hispanic, Pregnant Patient with Previously Undiagnosed Connective Tissue Disease

Authors

Christine Loftis, The University of Texas Rio Grande ValleyFollow
Emilia C. Dulgheru, The University of Texas Rio Grande Valley
Rosa White, The University of Texas Rio Grande Valley

Document Type

Article

Publication Date

11-17-2021

Abstract

Acquired factor VIII deficiency is a bleeding disorder caused by the presence of autoantibodies against clotting factor VIII. We report a case of a 24-year-old pregnant woman who presented with gross hematuria secondary to acquired factor VIII deficiency in the presence of a previously undiagnosed connective tissue disease. *is article includes a literature review of pregnancy-related cases of acquired factor VIII deficiency. We also reviewed various therapeutic approaches for the management of the acquired factor inhibitor which include achieving hemostasis and elimination of the inhibitor via immunosuppressive agents. *is case report describes the rare presentation of acquired factor VIII deficiency related to pregnancy and highlights the importance of considering a factor VIII inhibitor in the differential diagnosis of patients who present with bleeding and prolonged PTT during the peripartum and postpartum periods.

Comments

© 2021 Christine Loftis et al.

Recommended Citation

Loftis, C., Dulgheru, E. C., & White, R. (2021). Acquired Factor VIII Deficiency Presenting as Gross Hematuria in a Hispanic, Pregnant Patient with Previously Undiagnosed Connective Tissue Disease. Case reports in rheumatology, 2021, 3666270. https://doi.org/10.1155/2021/3666270

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Publication Title

Case reports in Rheumatology

DOI

10.1155/2021/3666270

Academic Level

faculty

Mentor/PI Department

Internal Medicine