Talks
Presentation Type
Oral Presentation
Discipline Track
Community/Public Health
Abstract Type
Research/Clinical
Abstract
Background: Chirality has been the most iconic phenomenon that occurred in nature. The idea of mirror-image asymmetry associated with the biological entity is still unsolved The emergence of 2D layered nanomaterials which have already shown amazing properties and a wide range of applications, especially in the areas of sensing.Amino acids enantiomers have similar physical and chemical properties however their physiological responses get changed based on the enantiomers. For example, L from amino acids helps body in protein formation, and generation of biological signals etc. whereas the D-form may cause toxic effects. We have developed a novel and facile synthesis method for producing chiral graphene for its application in the chirality-dependent sensing of amino acid enantiomers.
Methods: Initially L(D)-tyrosine was dispersed in milliQ water and then the graphite powder was stirred in the solution. Afterwards, the solution was subjected to bath sonication, followed by centrifugation to prepare colloidal dispersion of exfoliated graphene represented as L(D)-Graphene. For sensing-related studies known concentrations of L(D)-Graphene was deposited on carbon electrode and current-voltage were measured in the presence of different enantiomers of amino acids.
Results: The circular dichroism spectra confirmed the chirality present in the exfoliated L(D)-Graphene. Moreover, the Raman spectrum and transmission electron microscopy images confirmed the formation of multi-layer graphene with asymmetric morphology and a large aspect ratio. Chirality-dependent variation in the cyclic voltammetry curve was found with different enantiomers of amino acids.
Conclusions: The obtained results showed that L(D)-Graphene was stable for up to 1 month. In addition to that L(D)-Graphene exhibits a high aspect ratio and planar morphology and opens a new avenue for chiroptical sensors and devices.
Academic/Professional Position
Post-doc
Mentor/PI Department
Immunology and Microbiology
Recommended Citation
Pranav, Fnu; Ashraf, Ali; Jaggi, Meena; Chauhan, Subhash C.; and Yallapu, Murali M., "L(D)-tyrosine-mediated one-step chiral graphene production for chirality-dependent sensing" (2023). Research Symposium. 25.
https://scholarworks.utrgv.edu/somrs/2022/talks/25
Included in
Biology and Biomimetic Materials Commons, Medicine and Health Sciences Commons, Nanoscience and Nanotechnology Commons
L(D)-tyrosine-mediated one-step chiral graphene production for chirality-dependent sensing
Background: Chirality has been the most iconic phenomenon that occurred in nature. The idea of mirror-image asymmetry associated with the biological entity is still unsolved The emergence of 2D layered nanomaterials which have already shown amazing properties and a wide range of applications, especially in the areas of sensing.Amino acids enantiomers have similar physical and chemical properties however their physiological responses get changed based on the enantiomers. For example, L from amino acids helps body in protein formation, and generation of biological signals etc. whereas the D-form may cause toxic effects. We have developed a novel and facile synthesis method for producing chiral graphene for its application in the chirality-dependent sensing of amino acid enantiomers.
Methods: Initially L(D)-tyrosine was dispersed in milliQ water and then the graphite powder was stirred in the solution. Afterwards, the solution was subjected to bath sonication, followed by centrifugation to prepare colloidal dispersion of exfoliated graphene represented as L(D)-Graphene. For sensing-related studies known concentrations of L(D)-Graphene was deposited on carbon electrode and current-voltage were measured in the presence of different enantiomers of amino acids.
Results: The circular dichroism spectra confirmed the chirality present in the exfoliated L(D)-Graphene. Moreover, the Raman spectrum and transmission electron microscopy images confirmed the formation of multi-layer graphene with asymmetric morphology and a large aspect ratio. Chirality-dependent variation in the cyclic voltammetry curve was found with different enantiomers of amino acids.
Conclusions: The obtained results showed that L(D)-Graphene was stable for up to 1 month. In addition to that L(D)-Graphene exhibits a high aspect ratio and planar morphology and opens a new avenue for chiroptical sensors and devices.