Presentation Type
Poster
Discipline Track
Biomedical Science
Abstract Type
Research/Clinical
Abstract
Purpose: Nyctanthes arbor-tristis Linn., the lovely and fragrant flowering tree, sometimes called night-blooming jasmine or parijat, is native to Southeast and South Asia. For ages, this has been utilized in traditional medicine. There are claims that its leaves and blossoms have anti-inflammatory, antimicrobial, and anti-diabetic qualities. Plants contain anti-cancer capabilities; however, this has not yet been investigated. Therefore, we propose to explore mechanistic interaction with different cancer targets and active chemicals of this plant through computational methods, which will be further subjected to in vitro/in vivo experimental validation to show its anti-cancerous potentialities.
Description: Nyctanthes arbor-tristis Linn. plant contains several natural compounds like flavonoids, lignans, saponins, and napthoquinones. Nyctanthes arbor-tristis Linn. has been used for generations to treat various illnesses, including certain malignancies, in ancient medical systems like Ayurveda. These uses, however, require substantial scientific support as they are predicated on anecdotal evidence. One of the most important factors in carcinogenesis and the success of anticancer treatments is inflammation. Our latest research on anti-inflammatory activities reveals that natural chemicals from Nyctanthes arbor-tristis Linn. can interact with cyclooxygenase-2 (COX-2) and prostaglandin E2 (PGE2).Cyclooxygenase-2, or COX-2, is a multifunctional and intricate protein that frequently aids in the growth and metastasis of cancer. COX-2 catalyzes arachidonic acid to produce prostaglandins, the main by-product of which is PGE2.
PGE2 is a signaling molecule that affects the behavior of tumor cells in several ways. PGE2 promotes cell division in cancer cells and prevents apoptosis or programmed cell death. PGE2 encourages the creation of new blood vessels, which gives tumors the oxygen and nourishment they require for survival. PGE2 facilitates metastasis, or the spread of cancer cells to other organs, by improving their capacity to move and infiltrate surrounding tissues. PGE2 inhibits the immune system's ability to fight cancer, which makes it easier for cancer cells to avoid being found and destroyed. The overexpression of COX-2 stimulates many signaling pathways in cancer cells, augmenting their proliferation and endurance. COX-2 can become constitutively activated in cancer cells due to mutations in the genes controlling its expression. Natural chemicals derived from this plant may target cancer genes such as TP53 (tumor suppressor), KRAS (oncogene), BRCA1, BRCA2, and HER2 (breast cancer) to express their anti-cancer capabilities. Thus, the explored interaction of active chemicals of this plant with cyclooxygenase and other cancer targets will help to suggest alternative anticancer molecules from this plant.
Looking Ahead: The proposed computational analysis led by molecular interaction and molecular dynamics simulation will provide new insight into alternative anticancer potentialities of natural resources, which could prevent life-threatening diseases and avoid the initiation of tumors.
Academic/Professional Position
Community Partner
Recommended Citation
Jamal, Qazi Mohammad Sajid and Ahmad, Varish, "Assessment of Anti-cancerous properties of Nyctanthes arbor-tristis Linn natural compounds" (2024). Research Symposium. 75.
https://scholarworks.utrgv.edu/somrs/2024/posters/75
Included in
Assessment of Anti-cancerous properties of Nyctanthes arbor-tristis Linn natural compounds
Purpose: Nyctanthes arbor-tristis Linn., the lovely and fragrant flowering tree, sometimes called night-blooming jasmine or parijat, is native to Southeast and South Asia. For ages, this has been utilized in traditional medicine. There are claims that its leaves and blossoms have anti-inflammatory, antimicrobial, and anti-diabetic qualities. Plants contain anti-cancer capabilities; however, this has not yet been investigated. Therefore, we propose to explore mechanistic interaction with different cancer targets and active chemicals of this plant through computational methods, which will be further subjected to in vitro/in vivo experimental validation to show its anti-cancerous potentialities.
Description: Nyctanthes arbor-tristis Linn. plant contains several natural compounds like flavonoids, lignans, saponins, and napthoquinones. Nyctanthes arbor-tristis Linn. has been used for generations to treat various illnesses, including certain malignancies, in ancient medical systems like Ayurveda. These uses, however, require substantial scientific support as they are predicated on anecdotal evidence. One of the most important factors in carcinogenesis and the success of anticancer treatments is inflammation. Our latest research on anti-inflammatory activities reveals that natural chemicals from Nyctanthes arbor-tristis Linn. can interact with cyclooxygenase-2 (COX-2) and prostaglandin E2 (PGE2).Cyclooxygenase-2, or COX-2, is a multifunctional and intricate protein that frequently aids in the growth and metastasis of cancer. COX-2 catalyzes arachidonic acid to produce prostaglandins, the main by-product of which is PGE2.
PGE2 is a signaling molecule that affects the behavior of tumor cells in several ways. PGE2 promotes cell division in cancer cells and prevents apoptosis or programmed cell death. PGE2 encourages the creation of new blood vessels, which gives tumors the oxygen and nourishment they require for survival. PGE2 facilitates metastasis, or the spread of cancer cells to other organs, by improving their capacity to move and infiltrate surrounding tissues. PGE2 inhibits the immune system's ability to fight cancer, which makes it easier for cancer cells to avoid being found and destroyed. The overexpression of COX-2 stimulates many signaling pathways in cancer cells, augmenting their proliferation and endurance. COX-2 can become constitutively activated in cancer cells due to mutations in the genes controlling its expression. Natural chemicals derived from this plant may target cancer genes such as TP53 (tumor suppressor), KRAS (oncogene), BRCA1, BRCA2, and HER2 (breast cancer) to express their anti-cancer capabilities. Thus, the explored interaction of active chemicals of this plant with cyclooxygenase and other cancer targets will help to suggest alternative anticancer molecules from this plant.
Looking Ahead: The proposed computational analysis led by molecular interaction and molecular dynamics simulation will provide new insight into alternative anticancer potentialities of natural resources, which could prevent life-threatening diseases and avoid the initiation of tumors.