Posters
Presentation Type
Poster
Discipline Track
Biomedical Science
Abstract Type
Research/Clinical
Abstract
Background: Cancer is one of the essential unpredictable diseases worldwide; simultaneously, complicated issues created are by the human health system. Especially, breast cancer is the most commonly occurring cancer in women and is increasing remarkably in developing countries. It is a leading cause of cancer death in women, and breast cancer incidence rates are growing globally. To diagnose and treat cancer cells, different methods such as Radiation Therapy, Surgery, and Chemotherapy. These methods are high risk, more side effects, and high costs. The advanced healthcare material was developed to overcome this problem, inexpensive tools, and diagnosis of less-toxic drugs with negligible risk factors to normal cells. Nanoscience and nanotechnology fields can create higher prospects for diagnosing cancer cells using multifunctional nanomaterials for advanced clinical applications.
Methods: Mutifuntional ZnO-TiO2-sodium alginate hybrid nanomaterial was prepared by a simple precipitation process.
Results: ZnO-TiO2-Sodium alginate (ZTSAO) hybrid nanomaterial was successfully fabricated via a simple precipitation process. XRD patterns confirmed that the formation of ZTSAO crystal revealed a hexagonal wurtzite structure. The photoluminescence spectrum of ZTSAO, shows blue-green emissions at 480 nm and 484 nm, respectively, due to the active radicals generated in the nanomaterial, which are responsible for the associated anticancer activities. Invitro anticancer assay and the ZTSAO hybrid nanomaterial's toxicity effect were examined in cultured MDA-MB-237 breast cancer cells and L929 fibroblast cells.
Conclusions: In summary, ZTSAO hybrid nanomaterial has been developed against breast cancer cells (MDA-MB-237), and an IC50 concentration value of 10 μg/mL was recorded when evaluated after 24 h. Furthermore, the toxicity of ZTSAO hybrid nanomaterial treated cells indicates that the cells are alive with viability of ∼86.25 %, with results compared to the control group, showing that the ZTSAO hybrid nanomaterial exhibits minimum toxicity percentage. From this study, it is believed that ZTSAO hybrid nanomaterial is a highly promising nanomaterial, which will be suitable for advanced clinical applications.
Acknowledgments: The KC and KVP received support from the Fondecyt Postdoctoral Project No: 3190029 and Centro de Investigación de Polímeros Avanzados (CIPA), ANID/CONICYT Regional and GORE BIO-BIO R17A10003, Chile.
Academic/Professional Position
Post-doc
Recommended Citation
Karthikeyan, Chandrasekaran and Varaprasad, Kokkarachedu, "Biocidal properties of Hybrid Nanonanomaterial" (2023). Research Symposium. 28.
https://scholarworks.utrgv.edu/somrs/theme1/posters/28
Biocidal properties of Hybrid Nanonanomaterial
Background: Cancer is one of the essential unpredictable diseases worldwide; simultaneously, complicated issues created are by the human health system. Especially, breast cancer is the most commonly occurring cancer in women and is increasing remarkably in developing countries. It is a leading cause of cancer death in women, and breast cancer incidence rates are growing globally. To diagnose and treat cancer cells, different methods such as Radiation Therapy, Surgery, and Chemotherapy. These methods are high risk, more side effects, and high costs. The advanced healthcare material was developed to overcome this problem, inexpensive tools, and diagnosis of less-toxic drugs with negligible risk factors to normal cells. Nanoscience and nanotechnology fields can create higher prospects for diagnosing cancer cells using multifunctional nanomaterials for advanced clinical applications.
Methods: Mutifuntional ZnO-TiO2-sodium alginate hybrid nanomaterial was prepared by a simple precipitation process.
Results: ZnO-TiO2-Sodium alginate (ZTSAO) hybrid nanomaterial was successfully fabricated via a simple precipitation process. XRD patterns confirmed that the formation of ZTSAO crystal revealed a hexagonal wurtzite structure. The photoluminescence spectrum of ZTSAO, shows blue-green emissions at 480 nm and 484 nm, respectively, due to the active radicals generated in the nanomaterial, which are responsible for the associated anticancer activities. Invitro anticancer assay and the ZTSAO hybrid nanomaterial's toxicity effect were examined in cultured MDA-MB-237 breast cancer cells and L929 fibroblast cells.
Conclusions: In summary, ZTSAO hybrid nanomaterial has been developed against breast cancer cells (MDA-MB-237), and an IC50 concentration value of 10 μg/mL was recorded when evaluated after 24 h. Furthermore, the toxicity of ZTSAO hybrid nanomaterial treated cells indicates that the cells are alive with viability of ∼86.25 %, with results compared to the control group, showing that the ZTSAO hybrid nanomaterial exhibits minimum toxicity percentage. From this study, it is believed that ZTSAO hybrid nanomaterial is a highly promising nanomaterial, which will be suitable for advanced clinical applications.
Acknowledgments: The KC and KVP received support from the Fondecyt Postdoctoral Project No: 3190029 and Centro de Investigación de Polímeros Avanzados (CIPA), ANID/CONICYT Regional and GORE BIO-BIO R17A10003, Chile.