Talks
Presentation Type
Oral Presentation
Discipline Track
Biomedical Science
Abstract Type
Research/Clinical
Abstract
Background: Advanced drug delivery systems (DDSs) have received enormous attention in biomedical applications due to their pharmacodynamic and pharmacokinetic drug properties. For the present study, poly 4-hydroxyphenyl methacrylate (PHPMA)/CNOs (f-CNOs) inserted bovine serum albumin (BSA) nanofibers were prepared for stimuli-responsive release of Doxorubicin (DOX). Temperature and pH would be altered to study the release of DOX in acidic microenvironments.
Methods: PHPMA were coupled with COOH-CNOs via ester coupling via the sonochemical method to produce PHPMA-CNOs (f-CNOs). Then, f-CNOs/DOX embedded BSA nanofibers were prepared at room temperature using Forcespinning. UV spectra of DOX-loaded nanofibers were studied to investigate the release profile of DOX.
Results: The addition of f-CNOs to BSA fibers significantly increases thermal and mechanical properties (18.23 MPa). Also, fibers demonstrated long-termed thermosensitive DOX sustained-release obtaining 94% and 98.9% of drug release at 43 and 45 °C respectively in pH 5.0 over a 15-day study. Cytocompatibility studies with fibroblast cells showed good cell viability, cell adhesion, and proliferation against BSA/f-CNOs nanocomposite fibers.
Conclusión: The presented endogenous and exogenous stimuli-responsive drug delivery system could be useful in further cancer research studies and biomedical applications.
Academic/Professional Position
Graduate Student
Recommended Citation
Velasco Delgadillo, Ramiro Manuel and Mamidi, Narsimha, "Engineering of Functionalized Carbon Nano-Onions Embedded BSA Nanocomposite Fibers for Stimuli-Responsive Drug Release" (2023). Research Symposium. 17.
https://scholarworks.utrgv.edu/somrs/theme1/track1/17
Engineering of Functionalized Carbon Nano-Onions Embedded BSA Nanocomposite Fibers for Stimuli-Responsive Drug Release
Background: Advanced drug delivery systems (DDSs) have received enormous attention in biomedical applications due to their pharmacodynamic and pharmacokinetic drug properties. For the present study, poly 4-hydroxyphenyl methacrylate (PHPMA)/CNOs (f-CNOs) inserted bovine serum albumin (BSA) nanofibers were prepared for stimuli-responsive release of Doxorubicin (DOX). Temperature and pH would be altered to study the release of DOX in acidic microenvironments.
Methods: PHPMA were coupled with COOH-CNOs via ester coupling via the sonochemical method to produce PHPMA-CNOs (f-CNOs). Then, f-CNOs/DOX embedded BSA nanofibers were prepared at room temperature using Forcespinning. UV spectra of DOX-loaded nanofibers were studied to investigate the release profile of DOX.
Results: The addition of f-CNOs to BSA fibers significantly increases thermal and mechanical properties (18.23 MPa). Also, fibers demonstrated long-termed thermosensitive DOX sustained-release obtaining 94% and 98.9% of drug release at 43 and 45 °C respectively in pH 5.0 over a 15-day study. Cytocompatibility studies with fibroblast cells showed good cell viability, cell adhesion, and proliferation against BSA/f-CNOs nanocomposite fibers.
Conclusión: The presented endogenous and exogenous stimuli-responsive drug delivery system could be useful in further cancer research studies and biomedical applications.