Microwave-assisted polystyrene sulfonatecatalyzed synthesis of novel pyrroles

Authors

Rosario Astrid Vargas Cardenas, The University of Texas Rio Grande Valley
Blanca Olinda Quintanilla Leal, The University of Texas Rio Grande Valley
Ashwini Reddy, The University of Texas Rio Grande Valley
Debasish Bandyopadhyay, The University of Texas Rio Grande ValleyFollow
Bimal K. Banik, The University of Texas Rio Grande Valley

Document Type

Article

Publication Date

6-22-2012

Abstract

Background: Pyrroles are widely distributed in nature and important biologically active molecules. The reaction of amines with 2,5-dimethoxytetrahydrofuran is a promising pathway for the synthesis of pharmacologically active pyrroles under microwave irradiation.

Results: Microwave-induced polystyrenesulfonate-catalyzed synthesis of pyrroles from amines and 2,5- diemthoxytetrahydrofuran has been accomplished with excellent yield. This method produces pyrroles with polyaromatic amines.

Conclusion: The present procedure for the synthesis of N-aromatic substituted pyrroles will find useful application in the area of pharmacologically active molecules.

Comments

© 2012 Cárdenas et al.; licensee Springer.

Recommended Citation

Cárdenas, R. A. V., Leal, B. O. Q., Reddy, A., Bandyopadhyay, D., & Banik, B. K. (2012). Microwave-assisted polystyrene sulfonate-catalyzed synthesis of novel pyrroles. Organic and Medicinal Chemistry Letters, 2(1), 24. https://doi.org/10.1186/2191-2858-2-24

Creative Commons License

This work is licensed under a Creative Commons Attribution 3.0 License.

Publication Title

Organic and Medicinal Chemistry Letters

DOI

10.1186/2191-2858-2-24