Background: Pyrroles are widely distributed in nature and important biologically active molecules. The reaction of amines with 2,5-dimethoxytetrahydrofuran is a promising pathway for the synthesis of pharmacologically active pyrroles under microwave irradiation.
Results: Microwave-induced polystyrenesulfonate-catalyzed synthesis of pyrroles from amines and 2,5- diemthoxytetrahydrofuran has been accomplished with excellent yield. This method produces pyrroles with polyaromatic amines.
Conclusion: The present procedure for the synthesis of N-aromatic substituted pyrroles will find useful application in the area of pharmacologically active molecules.
Vargas Cardenas, Rosario Astrid; Quintanilla Leal, Blanca Olinda; Reddy, Ashwini; Bandyopadhyay, Debasish; and Banik, Bimal K., "Microwave-assisted polystyrene sulfonatecatalyzed synthesis of novel pyrroles" (2012). Chemistry Faculty Publications and Presentations. 100.
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Organic and Medicinal Chemistry Letters