Document Type

Article

Publication Date

2012

Abstract

Background: Pyrroles are widely distributed in nature and important biologically active molecules. The reaction of amines with 2,5-dimethoxytetrahydrofuran is a promising pathway for the synthesis of pharmacologically active pyrroles under microwave irradiation.

Results: Microwave-induced polystyrenesulfonate-catalyzed synthesis of pyrroles from amines and 2,5- diemthoxytetrahydrofuran has been accomplished with excellent yield. This method produces pyrroles with polyaromatic amines.

Conclusion: The present procedure for the synthesis of N-aromatic substituted pyrroles will find useful application in the area of pharmacologically active molecules.

Comments

© 2012 Cárdenas et al.; licensee Springer.

Creative Commons License

Creative Commons Attribution 3.0 License
This work is licensed under a Creative Commons Attribution 3.0 License.

Publication Title

Organic and Medicinal Chemistry Letters

DOI

10.1186/2191-2858-2-24

Included in

Chemistry Commons

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