Document Type

Article

Publication Date

2011

Abstract

Background: Eugenol, the main constituent of clove oil possesses a number of medicinal activities. To enhance the medicinal property, structural modification is required. On the other hand, bismuth nitrate pentahydrate has been established as an excellent eco-friendly nitrating agent for several classes of organic compounds.

Results: Bismuth nitrate pentahydrate-induced nitration of eugenol has been investigated very thoroughly. Twenty five different conditions have been studied. The microwave-induced solvent-free reaction has been identified as the best condition.

Conclusions: Spectral analyses confirm that 5-nitroeugenol is the sole product in all the cases. No oxidized or isomerized product could be detected.

Comments

Original published version available at https://dx.doi.org/10.1186/2191-2858-1-9

Publication Title

Organic and Medicinal Chemistry Letters

DOI

10.1186/2191-2858-1-9

Included in

Chemistry Commons

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