Bismuth nitrate pentahydrate-induced novel nitration of eugenol

Authors

Luis Canales, The University of Texas Rio Grande Valley
Debasish Bandyopadhyay, The University of Texas Rio Grande ValleyFollow
Bimal K. Banik, The University of Texas Rio Grande Valley

Document Type

Article

Publication Date

9-2011

Abstract

Background: Eugenol, the main constituent of clove oil possesses a number of medicinal activities. To enhance the medicinal property, structural modification is required. On the other hand, bismuth nitrate pentahydrate has been established as an excellent eco-friendly nitrating agent for several classes of organic compounds.

Results: Bismuth nitrate pentahydrate-induced nitration of eugenol has been investigated very thoroughly. Twenty five different conditions have been studied. The microwave-induced solvent-free reaction has been identified as the best condition.

Conclusions: Spectral analyses confirm that 5-nitroeugenol is the sole product in all the cases. No oxidized or isomerized product could be detected.

Comments

Original published version available at https://dx.doi.org/10.1186/2191-2858-1-9

Recommended Citation

Canales, L., Bandyopadhyay, D., & Banik, B. K. (2011). Bismuth nitrate pentahydrate-induced novel nitration of eugenol. Organic and Medicinal Chemistry Letters, 1(1), 9. https://doi.org/10.1186/2191-2858-1-9

Publication Title

Organic and Medicinal Chemistry Letters

DOI

10.1186/2191-2858-1-9