Background: The classical Strecker reaction is one of the simplest and most economical methods for the synthesis of racemic a-aminonitriles (precursor of a-amino acids) and pharmacologically useful compounds.
Results: Indium powder in water is shown to act as a very efficient catalyst for one-pot, three-component synthesis of a-aminonitriles from diverse amines, aldehydes and TMSCN. This general rapid method is applicable to a wide range of amines and aldehydes and produces products in excellent yield.
Conclusions: The present one-pot, three-component environmentally benign procedure for the synthesis of aaminonitriles will find application in the synthesis of complex biologically active molecules.
Bandyopadhyay, Debasish; Velazquez, Juliana M.; and Banik, Bimal K., "A truly green synthesis of a-aminonitriles via Strecker reaction" (2011). Chemistry Faculty Publications and Presentations. 112.
Organic and Medicinal Chemistry Letters