Glutathione, a peptide found in microbes, plants and animals including human plays a key role in maintaining healthy cells. The peptide exists in both reduced and oxidized forms. Synthesis of GSH occurs in the cytosol of cells, and the extent of glutathione synthesis relies on various factors, such as amino acid availability, protein activity etc. Once synthesized, glutathione exists in both forms: oxidized (GSSG) and reduced (GSH). Oxidized glutathione characterized by its disulfide linkage. On the other hand, presence of a thiol group characterizes the reduced glutathione. This thiol makes the tripeptide an essential component of health; it makes glutathione a free radical scavenger, or an antioxidant. Disturbance in glutathione synthesis or imbalance in GSH to GSSG ratio results in physiological conditions due to build up oxidants in cells. Imbalance might take place because of physiological conditions, or may result from hereditary conditions, or a disease developed from lifestyle. Dietary glutathione supplements are now being marketed. A concise overview of various aspects of glutathione in human body is presented in this mini-review.
Debasish Bandyopadhyay et al. (2018), Glutathione: A small molecule with big sense. Int J Pharm Sci & Scient Res. 4:5, 39-44.
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International Journal of Pharma Sciences and Scientific Research