A one-pot synthesis of benzo[f]indole-4,9-diones from 1,4-naphthoquinone with α-aminoacetals has been developed. This method provides a straightforward synthesis of benzo[f]indole-4,9-diones via intramolecular nucleophilic attack of aminoquinones to aldehydes under mild reaction conditions. The detailed mechanism was also investigated.
Luu, Q. H., Guerra, J. D., Castañeda, C. M., Martinez, M. A., Saunders, J., Garcia, B. A., Gonzales, B. V., Aidunuthula, A. R., & Mito, S. (2016). Ultrasound assisted one-pot synthesis of benzo-fused indole-4, 9-dinones from 1,4-naphthoquinone and α-aminoacetals. Tetrahedron letters, 57(21), 2253–2256. https://doi.org/10.1016/j.tetlet.2016.04.031