Document Type

Article

Publication Date

1-1-2009

Abstract

Background: Glucocorticoid is widely used as an anti-inflammatory drug in various diseases however excess of it often causes cardiovascular complications. The present study was undertaken to understand the molecular mechanism of glucocorticoid-induced cardiac dysfunction. Methods: Rats were treated daily with synthetic glucocorticoid, dexamethasone with or without mifepristone or losartan up to 15 days. Hemodynamic parameters were measured by PV-loop method using Millar's instrument. Cardiac remodelling, fibrosis and oxidative stress were monitored after 15 days. Results: The systolic blood pressure was increased whereas the heart beat and cardiac output (n=6) were decreased by dexamethasone. Dexamethasone caused increase in the heart weight to body weight ratio (P<0.001, n=20), increased level of mRNA of atrial natriuretic peptide and an increased deposition of collagens in the extracellular matrix of the left ventricle which were inhibited by both mifepristone and losartan. The rate of oxygen consumption was decreased in association with increased levels of hypoxia inducible factor 1α, lipid peroxidation (P<0.01, n=3) and superoxide dismutase activity (P<0.01, n=3) in dexamethasone treated rat heart. All these changes were reversed by mifepristone and losartan. Conclusions: The excess of glucocorticoid induces cardiac remodelling and pathophysiolgical changes of the myocardium via angiotensin II signalling pathway.

Comments

© 2009 the authors. Published under Creative Commons Attribution Non-Commercial No Derivatives License 4.0 International. Original published version available at http://doi.org/10.1159/000227803.

Ghose Roy, S., De, P., Mukherjee, R., et al. Excess of Glucocorticoid Induces Cardiac Dysfunction via Activating Angiotensin II Pathway. Cellular Physiology and Biochemistry 2009, vol. 24, 1-10.

First Page

1

Last Page

10

Publication Title

Cellular Physiology and Biochemistry

DOI

10.1159/000227803

Included in

Chemistry Commons

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