Document Type

Article

Publication Date

1-1-2012

Abstract

Polycyclic aromatic hydrocarbons (PAHs) are considered to be significant environmental carcinogens. Additionally, various planar ring systems are capable of intercalating with DNA, leading to a number of drugs that possess chemotherapeutic activity. In this study, three new polyaromatic compounds with a side chain were synthesized, and spectroscopic as well as elemental analyses were performed. The addition of the long chains to either chrysene or pyrene caused a red-shift in the spectral emission when compared to the corresponding polycyclic aromatic hydrocarbons itself. Furthermore, the cytotoxicity of the three novel polyaromatic compounds was evaluated in vitro in a panel of cultured mammalian cell lines. The pyrenyl ether demonstrated better cytotoxicity compared to cisplatin against colon (HT-29) as well as cervical (HeLa) cancer cell lines. In conclusion, three new compounds were synthesized and investigated in this study. This novel method is likely to play a role in other areas of research.

Comments

© 2012 Spandidos Publishing. Original published version available at http://doi.org/10.3892/ol.2011.436.

Bandyopadhyay, D., Granados, J., Short, R., et al. Polycyclic Aromatic Compounds As Anticancer Agents: Evaluation of Synthesis and in Vitro Cytotoxicity. Oncology Letters 2012, vol. 3, 45-49.

First Page

45

Last Page

49

Publication Title

Oncology Letters

DOI

10.3892/ol.2011.436

Included in

Chemistry Commons

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