STEREOSELECTIVITY OF PHTHALIMIDO β-LACTAMS FORMATION: SYNTHESIS OF 3-AMINO β-LACTAMS THROUGH A FACILE DEPROTECTION REACTION

Authors

Armando Paniagua, The University of Texas Rio Grande Valley
Ram Naresh Yadav
Sunena Chandra, The University of Texas Rio Grande Valley
Bimal K. Banik, The University of Texas Rio Grande ValleyFollow

Document Type

Article

Publication Date

2018

Abstract

Synthesis of amino β-lactams is a crucial objective because of the medicinal properties associated with them and the products derived from of them. Stereocontrolled synthesis of phthalimido β-lactams is performed and cis and trans-phthalimido β-lactams are deprotected with ethylene diamine (and other reagents) to amino β-lactams of diverse structures in excellent yield. This reaction is also conducted under solventless conditions to afford identical products.

Comments

Original published version available here.

Recommended Citation

Paniagua, A., Yadav, R. N., Chandra, S., & Banik, B. K. (2018). STEREOSELECTIVITY OF PHTHALIMIDO β-LACTAMS FORMATION: SYNTHESIS OF 3-AMINO β-LACTAMS THROUGH A FACILE DEPROTECTION REACTION. Heterocyclic Letters, 8(2), 287–295.

First Page

287

Last Page

295

Publication Title

Heterocyclic Letters