Background: The classical Paal-Knorr reaction is one of the simplest and most economical methods for the synthesis of biologically important and pharmacologically useful pyrrole derivatives.
Results: Polystyrenesulfonate-catalyzed simple synthesis of substituted pyrroles following Paal-Knorr reaction has been accomplished with an excellent yield in aqueous solution. This method also produces pyrroles with multicyclic polyaromatic amines.
Conclusions: The present procedure for the synthesis of N-polyaromatic substituted pyrroles will find application in the synthesis of potent biologically active molecules.
Banik, Mandira; Ramirez, Bianca; Reddy, Ashwini; Bandyopadhyay, Debasish; and Banik, Bimal K., "Polystyrenesulfonate-catalyzed synthesis of novel pyrroles through Paal-Knorr reaction" (2012). Chemistry Faculty Publications and Presentations. 99.
Creative Commons License
This work is licensed under a Creative Commons Attribution 3.0 License.
Organic and Medicinal Chemistry Letters