Document Type


Publication Date



Fruit extracts may be cardioprotective via favorable modulation of platelet-blood vessel interaction. We here show that sugar-free extracts of tamarillo, horned melon (kiwano), and raspberry in a dose-dependent manner inhibited ADP-induced platelet aggregation in platelet-rich plasma. In contrast, pear extract had no such effect. Furthermore, analysisof untargeted metabolites revealed the presence of platelet inhibitory components such as benzoic acid, caffeic acid, and gallic acid in the sugar-free extracts of tamarillo, raspberry, and kiwano, but not in pear extract. All these three fruit extracts inhibited the platelet production of TxB2 and the release of platelet factor 4. In conclusion, our work suggests that tamarillo, raspberry, and kiwano inhibit platelet aggregation partly due to the high levels of anti-platelet compounds such as benzoic, caffeic, and gallic acids.

Creative Commons License

Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.

Included in

Food Science Commons


To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.