Human Genetics Publications and Presentations
Document Type
Article
Publication Date
4-11-2025
Abstract
Here, we present a multi-omics study of type 2 diabetes and quantitative blood lipid and lipoprotein traits conducted to date in Hispanic/Latino populations (nmax = 63,184). We conduct a meta-analysis of 16 type 2 diabetes and 19 lipid trait GWAS, identifying 20 genome-wide significant loci for type 2 diabetes, including one novel locus and novel signals at two known loci, based on fine-mapping. We also identify sixty-one genome-wide significant loci across the lipid/lipoprotein traits, including nine novel loci, and novel signals at 19 known loci through fine-mapping. Next, we analyze genetically regulated expression, perform Mendelian randomization, and analyze association with transcriptomic and proteomic measure using multi-omics data from a Hispanic/Latino population. Using this approach, we identify genes linked to type 2 diabetes and lipid/lipoprotein traits, including TMEM205 and NEDD9 for HDL cholesterol, TREH for triglycerides, and ANXA4 for type 2 diabetes.
Recommended Citation
Petty, L. E., Chen, H. H., Frankel, E. G., Zhu, W., Downie, C. G., Graff, M., ... & Global Hispanic Lipids Consortium. (2025). Large-scale multi-omics analyses in Hispanic/Latino populations identify genes for cardiometabolic traits. Nature communications, 16(1), 3438. https://doi.org/10.1038/s41467-025-58574-z
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Publication Title
Nature Communications
DOI
10.1038/s41467-025-58574-z
Comments
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