Theses and Dissertations - UTB/UTPA
Date of Award
Master of Science (MS)
Dr. Daniel Plas
Dr. Robert Gilkerson
Dr. Hassan Ahmad
Parkinson’s disease (PD) is the most common neurodegenerative movement disorder, characterized by progressive depletion of dopamine (DA). Rotenone, a common pesticide, can induce PD like symptoms in animal models. The goal of this thesis is to quantify the levels and effects of reactive oxygen species (ROS) in brain tissue of the common neurobiological gastropod model, Lymnaea stagnalis, after treatment with Rotenone. The results show that rotenone causes a behavioral deficit and increases ROS production, especially superoxide. Furthermore, glutathione was depleted and protein carbonyl formation increased. These results are consistent with findings in human PD and the high levels of ROS we find in the Lymnaea model suggest that it is a useful avenue to explore the possible causative role of oxidative stress in dopaminergic neurodegeneration.
University of Texas-Pan American
Copyright 2015 Daniel Plas. All Rights Reserved.