Theses and Dissertations - UTB/UTPA
Date of Award
Master of Science (MS)
Dr. Mohammed Farooqui
Dr. Robert I. Lonard
Dr. Sammie L. Sides
This study examined the comparative toxicities and metabolism of four selected aminonitriles namely aminoacetonitrile, $\beta$-aminopropionitrile, $N,N\sp\prime$-dimethylaminopropionitrile, and $\beta ,\beta\sp\prime$-iminodipropionitrile. Various experiments in this study include time course of the metabolism of these nitriles to cyanide, thiocyanate, and cyanoacetic acid. All of the nitriles studied were metabolized to cyanide and thiocyanate and the levels of these metabolites remained at a significantly high level even 5 days after dosing. Except aminoacetonitrile all the nitriles were metabolized to cyanoacetic acid. Experiments on the role of vehicles on the toxicity and metabolism of nitriles showed that all of the vehicles studied significantly affected nitrile metabolism to their respective metabolites. All of the nitriles were capable of depleting glutathione (GSH) indicating that they are metabolized via a GSH detoxicating pathway with a reactive intermediate such us aldehydes.
University of Texas-Pan American
Copyright 1994 Timothy Lester Lacy. All Rights Reserved.