Theses and Dissertations - UTB/UTPA
Date of Award
Master of Science (MS)
Dr. Mohammed Farooqui
Dr. Robert I. Lonard
Dr. Scott J. Gunn
This study examined the effects of ethanol on the toxicities and metabolism of two aliphatic nitriles: acetonitrile and acrylonitrile (one unsaturated and one saturated aliphatic nitrile, respectively) in male Sprague-Dawley rats at four different time intervals. Toxicity signs were apparent in all animals given the nitrile dosage, but those treated with ethanol dosages showed signs of toxicity earlier than those treated with glucose dosages. Both of the nitrites were metabolized to cyanide and thiocyanate. The concentration levels of each metabolite was apparent at 2 and 3 g/kg ethanol dosage for acetonitrile and 3 and 4.5 g/kg ethanol dosage for acrylonitrile at 12 hours indicating that ethanol is inhibiting the metabolism of the respective nitrile at those concentrations. The data also showed that the ethanol is capable of depleting glutathione (GSH), but there was no clear pattern as to the ethanol dosage administered.
University of Texas-Pan American
Copyright 2002 Nancy Ochoa-Garza. All Rights Reserved.