Theses and Dissertations - UTB/UTPA
Synthesis and Characterization of Biodegradable Electrospun Polyurethanes For Biomedical Applications
Date of Award
Master of Science (MS)
Dr. Javier Macossay-Torres
Dr. Bimal K. Banik
Dr. Elamin E. Ibrahim
Two types of polyesters [(Poly(ε-caprolactone) and Poly(δ-valerolactone)] were synthesized by ring-opening polymerization with diethylene glycol as a initiator and stannous octate as a catalyst. The corresponding polyurethanes were synthesized by two-step polymerization with 1,4-diisocyanate butane (BDI) and reacted with 1,4-diamino butane (Putrescine) chain extender. The polymers were characterized by Proton Nuclear Magnetic Resonance (1H NMR), Fourier Transform Infrared Spectroscopy (FT-IR), Raman Spectroscopy, Size-exclusive Chromatography (SEC), Thermogravimetric Analysis (TGA) and Differential Scanning Calorimetry (DSC). The resulting polyurethanes were fabricated into nanofibers using an electrospinning technique. The morphological, structural characterizations and thermal properties of the bulk polyurethanes and electrospun polyurethanes nanofibers were analyzed by Scanning Electron Microscopy (SEM), FT-IR, Raman, TGA and DSC. The degradability of electrospun polyurethane nanofibers were investigated in phosphate buffer solution (pH=7.2) at 37°C at a period of 5 days.
University of Texas-Pan American
Copyright 2012 Xujun Zhang. All Rights Reserved.