Theses and Dissertations - UTB/UTPA

Date of Award


Document Type


Degree Name

Master of Science (MS)



First Advisor

Dr. Elamin E. Ibrahim

Second Advisor

Dr. Hassan Ahmad

Third Advisor

Dr. Narayan G. Bhat


β-lactam antibiotics which is a class by itself, covers a wide range of antibiotics that includes penicillin, penicillin derivatives, cephalosporins, carbapenems, and any antibiotic agent that contains a 2-azetidinone ring.[2] In recent past research it has been established that β-lactams show therapeutic and anticancer activity with low toxicity. [2] It has also been reported by our lab that N-chrysenyl and N-phenanthrenyl 3-acetoxy-4-aryl-2- azetidinone can exhibit potent selective anticancer activity towards prostate, colon, pancreatic cancer and leukemia at low concentrations, all of this was revealed by means of a structure activity study. [2] The goal of our research is the synthesis of a β-lactam that contains a hydroxy group at the one carbon spacer of the third carbon belonging to the 2- azetidinone ring system.


Copyright 2010 Mohamed Hashim. All Rights Reserved.β-lactams/docview/726038636/se-2

Granting Institution

University of Texas-Pan American

Included in

Chemistry Commons