Theses and Dissertations - UTB/UTPA
Date of Award
Master of Science (MS)
Dr. Elamin E. Ibrahim
Dr. Hassan Ahmad
Dr. Narayan G. Bhat
β-lactam antibiotics which is a class by itself, covers a wide range of antibiotics that includes penicillin, penicillin derivatives, cephalosporins, carbapenems, and any antibiotic agent that contains a 2-azetidinone ring. In recent past research it has been established that β-lactams show therapeutic and anticancer activity with low toxicity.  It has also been reported by our lab that N-chrysenyl and N-phenanthrenyl 3-acetoxy-4-aryl-2- azetidinone can exhibit potent selective anticancer activity towards prostate, colon, pancreatic cancer and leukemia at low concentrations, all of this was revealed by means of a structure activity study.  The goal of our research is the synthesis of a β-lactam that contains a hydroxy group at the one carbon spacer of the third carbon belonging to the 2- azetidinone ring system.
University of Texas-Pan American
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