Theses and Dissertations - UTB/UTPA
Date of Award
Master of Science (MS)
Dr. Jason Parsons
Dr. Jose J. Gutierrez
Dr. K. Christopher Smith
The microwave-induced reaction for the synthesis of nitrogen containing heterocyclesis very important in medicinal chemistry. The synthesis of various other valuable compounds is also done by employing this reaction. The aza Diels-Alder reaction is one of the most powerful synthetic tools for the synthesis of nitrogen containing heterocycles. The main goal of the research is to synthesize the nitrogen containing heterocycles using Bismuth nitrate as the catalyst in the presence of microwave irradiation. In the present study we explore the catalytic activity of bismuth nitrate and the role of microwave reactor in the synthesis of 2, 3-diaryl substituted bicyclic octanone which is the integral part of various biologically active natural products. Compared to conventional heating the microwave reaction was found to be more effective and efficient.These molecules posses acetyl cholinesterase inhibitory properties.
University of Texas-Pan American
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