Theses and Dissertations - UTB/UTPA

Date of Award


Document Type


Degree Name

Master of Science (MS)



First Advisor

Dr. Jason Parsons

Second Advisor

Dr. Hassan Ahmad

Third Advisor

Dr. James Bullard


The field of nanomedicine has recently explored potential applications for cancer treatment ranging from drug delivery methods to cancer imaging techniques. Due to potential risks of nanomaterials affecting non-cancerous cells in the body, in vitro toxicity studies are being conducted. The nanoparticles (NPs) were synthesized from potassium tetrachloroaurate (III) hydrate, potassium tetrabromoaurate (III) dihydrate, potassium tetrachloropalladate (II), and silver nitrate. NPs were synthesized using the Turkevich method or through the sodium borohydride reduction. Particles synthesized using sodium borohydride were stabilized with cetyltrimethylammonium bromide (CTAB). The NPs under investigation were used to treat three cancer cell lines. The treated cells were incubated for 24 h and analyzed using the MTT assay to measure proliferation. In addition, the concentrations of each metal engaged with the live cancer cells were determined via acid digestion and ICP-OES quantification of metal uptake. TEM images and XRD patterns show size and morphology upon NP synthesis.


Copyright 2013 M. Esther Salinas. All Rights Reserved.

Granting Institution

University of Texas-Pan American

Included in

Chemistry Commons