Centrifugally spun mats based on biopolyesters/hydroxyapatite and their potential as bone scaffolds

Authors

Victoria M. Padilla-Gainza, The University of Texas Rio Grande ValleyFollow
Heriberto Rodríguez-Tobías
Graciela Morales
Eduardo Saucedo
Karen Lozano, The University of Texas Rio Grande ValleyFollow
Vanessa Montaño-Machado,
Diego Mantovani

Document Type

Article

Publication Date

4-10-2021

Abstract

This work studied the potential of centrifugal spinning for the production of fibrous materials based on poly(D,L-lactic acid) (PDLLA) and poly(3-hydroxybutyrate) (PHB) with hydroxyapatite nanoparticles (n-Hap). The influence of n-Hap concentration (5, 10, and 15 wt.%) and spinneret angular speed on the final fiber morphology were analyzed. Further experimental evaluations were implemented to determine the effect of n-Hap on the thermal and mechanical performance. The optimum parameters that show a balance among high yield production of homogeneous fibers with the smallest fiber average diameter were found to be at 5 wt.% of n-Hap processed at 7000 rpm for PDLLA, and 5, 10, and 15 wt.% of n-Hap at 6000 rpm for PHB. The thermal stability, for both systems, was not significantly affected. The mechanical performance of PHB systems was improved with the addition of n-Hap. Osteoblast cell viability tests depicted a favorable cell response on the PDLLA systems.

Comments

© 2020 Wiley Periodicals LLC.

https://onlinelibrary.wiley.com/share/ZT34KKXJWIEWTNXEVN7Y?target=10.1002/app.50139

Recommended Citation

Padilla‐Gainza, Victoria M., Heriberto Rodríguez‐Tobías, Graciela Morales, Esmeralda Saucedo‐Salazar, Karen Lozano, Vanessa Montaño‐Machado, and Diego Mantovani. "Centrifugally spun mats based on biopolyesters/hydroxyapatite and their potential as bone scaffolds." Journal of Applied Polymer Science 138, no. 14 (2021): app50139. https://doi.org/10.1002/app.50139

Publication Title

Journal of Applied Polymer Science

DOI

10.1002/app.50139