Objective: To evaluate the relationship between total and differential White Blood Cell (WBC) counts with time to transition to type 2 diabetes in Mexican Americans using prospective data from the Cameron County Hispanic Cohort (CCHC).
Results: Multivariable Cox proportional hazards regression models revealed that obese Mexican-American cohort participants whose total WBC or granulocyte count increased over time had 1.39 and 1.35 times higher risk respectively of transition to type 2 diabetes when compared to overweight participants. The granulocyte or total WBC count in participants with BMI≥35 were significant risk factors for transition to type 2 diabetes.
Conclusions: Increased total WBC and WBC differential counts, particularly lymphocytes and granulocytes, are associated with risk of transition to type 2 diabetes in obese Mexican Americans, after adjusting for other potential confounders. Screening and monitoring the WBC counts, including lymphocytes and granulocytes can help with monitoring potential transition to type 2 diabetes.
Vatcheva KP, Fisher-Hoch SP, Rahbar MH, Lee MJ, Olvera RL, Mccormick JB. Association of total and differential white blood cell counts to development of type 2 diabetes in Mexican Americans in Cameron county Hispanic cohort. Diabetes Res Open J. 2015; 1(4): 103-112. doi: 10.17140/DROJ-1-117
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Diabetes Res Open J