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STAT1 has been shown to have tumor suppressive or protumorigenic roles in tissues in a context-dependent manner. In this study, we explored the role of TC-PTP in the regulation of STAT1 during skin tumor promotion. We found that the levels of the phosphorylated serine form of STAT1 were increased in TC-PTP overexpressing keratinocytes in response to TPA treatment. Additionally, TC-PTP overexpression decreased TPA-induced proliferation through regulation of STAT1 signaling. These results suggest that positive regulation of STAT1 signaling via TC-PTP can have a protective role towards keratinocytes during tumor promotion. These findings suggest that targeting TC-PTP-mediated regulation of STAT1 signaling could have therapeutic implications for treating or preventing skin cancer.

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medical student

Available for download on Thursday, November 18, 2021

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Diseases Commons