Space medicine is becoming an essential and expanding clinical discipline. Acquiring a deeper and complete picture understanding of the multi-systemic response due to space on human health and function is essential to ensure the success of future space exploration. A comprehensive review of the literature was performed using PubMed and focused on the current neurophysiologic findings of the central nervous system’s response to space. Ground-based analogues, which mimic the effects of microgravity, and actual spaceflight studies have been used to analyze these physiologic adaptations to space. Overall, cerebellar, sensorimotor and vestibular brain regions seem to be affected the most. Through these and future studies, the goal should be to extend the distance that humans go into space and to increase the time that they can stay there.
Velasquez, Jose R., "Neurophysiology of Space Medicine: A Literature Review" (2021). MEDI 9331 Scholarly Activities Clinical Years. 45.