Document Type
Poster
Publication Date
2024
Abstract
The relationship between periodontitis and Alzheimer's disease (AD) has garnered significant attention due to the potential influence of chronic oral inflammation on neurodegenerative processes. Our hypothesis is supported by the oral-microbiome-brain axis and highlights the possibility that chronic periodontitis contributes to cognitive decline by promoting systemic inflammation and neuroinflammation, mediated by specific pathogenic microorganisms within the oral microbiome. Our findings reveal a strong association between elevated levels of Porphyromonas gingivalis and Treponema denticola, red complex bacteria, and markers of systemic inflammation, such as C-reactive protein (CRP) and pro-inflammatory cytokines. Additionally studies have demonstrated that beta amyloid plaque in rat brains contain both organisms further supporting the potential link and role of oral microbes in the exacerbation or onset of Alzheimers disease. Our review aims to synthesize current evidence assessing the association between periodontitis and Alzheimer's disease, with a focus on the oral-microbiome-brain axis as a key mechanistic pathway.
Recommended Citation
Al Hassan, Taha; Al-Hassan, Noah; Quiñones-Peña, Maria; Lopez-Alvarenga, Juan; and Guadarrama-Beltran, Seratna, "The Oral-Microbiome-Brain Axis: A Thorough Review on the Relationship between Periodontitis and Alzheimer’s Disease and a Proposed Innovative Application of Biomagnetism as a Means of Alternative Therapy." (2024). MEDI 9331 Scholarly Activities Clinical Years. 85.
https://scholarworks.utrgv.edu/som9331/85
Academic Level
medical student
Mentor/PI Department
Immunology and Microbiology
Included in
Alternative and Complementary Medicine Commons, Bacteria Commons, Other Medicine and Health Sciences Commons, Physics Commons