Document Type

Article

Publication Date

12-2019

Abstract

mesoscopic physics-based optical imaging technique, partial wave spectroscopy (PWS), has been used for the detection of cancer by probing nanoscale structural alterations in cells/tissue. The development of drug-resistant cancer cells/tissues during chemotherapy is a major challenge in cancer treatment. In this paper, using a mouse model and PWS, the structural properties of tumor tissue grown in 3D structures by xenografting drug-resistant and drug-sensitive human prostate cancer cells having 2D structures, are studied. The results show that the 3D xenografted tissues maintain a similar hierarchy of the degree of structural disorder properties as that of the 2D original drug-sensitive and drug-resistant cells.

Comments

© 2019 Optical Society of America under the terms of the OSA Open Access Publishing Agreement. Original published version available at https://doi.org/10.1364/BOE.10.006422

First Page

6422

Last Page

6431

Publication Title

Biomedical Optics Express

DOI

10.1364/BOE.10.006422

Academic Level

faculty

Mentor/PI Department

Immunology and Microbiology

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