mesoscopic physics-based optical imaging technique, partial wave spectroscopy (PWS), has been used for the detection of cancer by probing nanoscale structural alterations in cells/tissue. The development of drug-resistant cancer cells/tissues during chemotherapy is a major challenge in cancer treatment. In this paper, using a mouse model and PWS, the structural properties of tumor tissue grown in 3D structures by xenografting drug-resistant and drug-sensitive human prostate cancer cells having 2D structures, are studied. The results show that the 3D xenografted tissues maintain a similar hierarchy of the degree of structural disorder properties as that of the 2D original drug-sensitive and drug-resistant cells.
Adhikari, Prakash A.; Nagesh, Prashanth K.B.; Alharthi, Fatemah; Chauhan, Subhash C.; Jaggi, Meena; Yallapu, Murali M.; and Pradhan, Prabhakar, "Optical detection of the structural properties of tumor tissue generated by xenografting of drug-sensitive and drug-resistant cancer cells using partial wave spectroscopy (PWS)" (2019). School of Medicine Publications and Presentations. 104.
Biomedical Optics Express
Immunology and Microbiology