Neutralizing antibodies (NAs) are key immunological markers and are part of the humoral response of the adaptive immune system. NA assays determine the presence of functional antibodies to prevent SARS-CoV-2 infection. We performed a real-world evidence study to detect NAs that confer protection against SARS-CoV-2 after the application of five vaccines (Pfizer/BioNTech, AstraZeneca, Sinovac, Moderna, and CanSino) in the Mexican population. Side effects of COVID-19 vaccines and clinical and demographic factors associated with low immunogenicity were also evaluated. A total of 242 SARS-CoV-2-vaccinated subjects were recruited. Pfizer/BioNTech and Moderna proved the highest percentage of inhibition in a mono-vaccine scheme. Muscular pain, headache, and fatigue were the most common adverse events. None of the patients reported severe adverse events. We found an estimated contagion-free time of 207 (IQR: 182–231) and 187 (IQR: 184–189) days for Pfizer/BioNTech and CanSino in 12 cases in each group. On the basis of our results, we consider that the emerging vaccination strategy in Mexico is effective and safe.
Alcorta-Nuñez F, Pérez-Ibave DC, Burciaga-Flores CH, Garza MÁ, González-Escamilla M, Rodríguez-Niño P, González-Guerrero JF, Alcorta-Garza A, Vidal-Gutiérrez O, Ramírez-Correa GA, et al. SARS-CoV-2 Neutralizing Antibodies in Mexican Population: A Five Vaccine Comparison. Diagnostics. 2023; 13(6):1194. https://doi.org/10.3390/diagnostics13061194
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