School of Medicine Publications and Presentations

The Relationship Between Segmental Pulse Wave Velocity And Hemodynamic Variables In Young Hispanic Individuals.

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Arterial stiffness is positively correlated with systolic hypertension and is used as a predictor of adverse cardiovascular events. However, detailed examination of associations between arterial stiffness and other hemodynamic variables may provide new information related to factors such as gender and race.

PURPOSE: To examine the correlations between segmental pulse wave velocity (PWV) and other hemodynamic variables among Hispanic college-aged males and females.METHODS: Forty-six female (age= 22.7 ± 4.1) and thirty-nine male (age= 24.7 ± 6.2) subjects had their hydration leves assessed by clinical urine refractometry following an overnight fast of at least 8 hours. Pulse wave velocity (PWV) and other hemodynamic variables including large and small arterial elasticity were measured non-invasively using SphygmoCorand HDI/PulseWave CR-2000, respectively.

RESULTS: For females, femoral to dorsalis pedis PWV (fdPWV) was significantly correlated with systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean arterial pressure (MAP) (r= 0.357, r= 0.364, r= 0.419, p<0.02, respectively). Carotid to femoral PWV (cfPWV) was significantly correlated with weight, SBP, pulse pressure (PP), and cardiac output (CO) (r=0.376, r= 0.325, r= 0.358, r= 0.312, p<0.04, respectively). Carotid to radial PWV (crPWV) was only significantly correlated with DBP (r= 0.461, p<0.01). For males, fdPWV was only significantly correlated with large arterial elasticity (r = - 0.332, p= 0.04). cfPWV was significantly correlated with weight, SBP, DBP, MAP, and CO (r= 0.469, r= 0.387, r= 0.522, r= 0.380, and r= 0.358, p<0.03, respectively). crPWV was significantly correlated with weight, SBP, DBP, MAP, cardiac ejection time (CET), and stroke volume (SV) (r= 0.445, r= 0.386, r= 0.376, r= 0.334, r= 0.412, and r= 0.468, p <0.04, respectively).

CONCLUSIONS: The findings suggest that the associations between hemodynamic variables and segmental PWV were affected by gender. Weight, SBP, and CO were correlated with cfPWV and DBP was only correlated with crPWV for both genders. No single hemodynamic variable correlated with fdPWV that was common to both genders. The findings of the study may have a practical use by clinicians to predict and/or prevent future cardiovascular events in young Hispanic individuals.


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Medicine & Science in Sports & Exercise



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Office of Human Genetics