Lack of Association between SLC30A8 Variants and Type 2 Diabetes in Mexican American Families

Authors

Hemant Kulkarni, The University of Texas Rio Grande Valley
Manju Mamtani, The University of Texas Rio Grande Valley
Juan M. Peralta, The University of Texas Rio Grande Valley
Vincent P. Diego, The University of Texas Rio Grande Valley
Thomas D. Dyer, The University of Texas Rio Grande Valley
Harald H. H. Goring, The University of Texas Rio Grande Valley
Laura Almasy, The University of Texas Rio Grande Valley
Sarah Williams-Blangero, The University of Texas Rio Grande Valley
Michael C. Mahaney, The University of Texas Rio Grande Valley
Ravindranath Duggirala, The University of Texas Rio Grande Valley
Joanne E. Curran, The University of Texas Rio Grande Valley
John Blangero, The University of Texas Rio Grande Valley

Document Type

Article

Publication Date

11-2016

Abstract

SLC30A8 encodes zinc transporter 8 which is involved in packaging and release of insulin. Evidence for the association of SLC30A8 variants with type 2 diabetes (T2D) is inconclusive. We interrogated single nucleotide polymorphisms (SNPs) around SLC30A8 for association with T2D in high-risk, pedigreed individuals from extended Mexican American families. This study of 118 SNPs within 50 kb of the SLC30A8 locus tested the association with eight T2D-related traits at four levels: (i) each SNP using measured genotype approach (MGA); (ii) interaction of SNPs with age and sex; (iii) combinations of SNPs using Bayesian Quantitative Trait Nucleotide (BQTN) analyses; and (iv) entire gene locus using the gene burden test. Only one SNP (rs7817754) was significantly associated with incident T2D but a summary statistic based on all T2D-related traits identified 11 novel SNPs.Three SNPs and one SNP were weakly but interactively associated with age and sex, respectively. BQTN analyses could not demonstrate any informative combination of SNPs over MGA. Lastly, gene burden test results showed that at best the SLC30A8 locus could account for only 1-2% of the variability in T2D-related traits. Our results indicate a lack of association of the SLC30A8 SNPs with T2D in Mexican American families.

Comments

© 2016 Hemant Kulkarni et al. Original published version available at http://dx.doi.org/10.1155/2016/6463214

Recommended Citation

Kulkarni, H., Mamtani, M., Peralta, J. M., Diego, V., Dyer, T. D., Goring, H., Almasy, L., Mahaney, M. C., Williams-Blangero, S., Duggirala, R., Curran, J. E., & Blangero, J. (2016). Lack of Association between SLC30A8 Variants and Type 2 Diabetes in Mexican American Families. Journal of Diabetes Research, 2016, e6463214. https://doi.org/10.1155/2016/6463214

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Publication Title

Journal of Diabetes Research

DOI

10.1155/2016/6463214

Academic Level

faculty

Mentor/PI Department

Office of Human Genetics