School of Medicine Publications and Presentations

Routes of Stem Cell Administration

Document Type

Conference Proceeding

Publication Date



Stem cells are very promising for the treatment of a plethora of human diseases. Numerous clinical studies have been conducted to assess the safety and efficacy of various stem cell types. Factors that ensure successful therapeutic outcomes in patients are cell-based parameters such as source, viability, and number, as well as frequency and timing of intervention and disease stage. Stem cell administration routes should be appropriately chosen as these can affect homing and engraftment of the cells and hence reduce therapeutic effects, or compromise safety, resulting in serious adverse events. In this chapter, we will describe the use of stem cells in organ repair and regeneration, in particular, the liver and the available routes of cell delivery in the clinic for end-stage liver diseases. Factors affecting homing and engraftment of stem cells for each administration route will be discussed.


© 2022 The Author(s), under exclusive license to Springer Nature Switzerland AG.

Publication Title

Advances in Mesenchymal Stem Cells and Tissue Engineering



Academic Level


Mentor/PI Department

Immunology and Microbiology