Document Type

Article

Publication Date

2019

Abstract

This manuscript describes the design and synthesis of a series of diverse N-Acyl Anthranilamides and quinazolin-4-ones derivatives (3a-3n, and 4a-4d) inhibitors of HMG-CoA reductase for the treatment of hypercholesterolemia. A series of N-Acyl Anthranilamides and quinazolin-4-ones derivatives (3a-3n, and 4a-4d) were synthesized and their chemical structures were confirmed by 1 H, 13C NMR and mass spectral data. Analogs were optimized using structure-based design and physical property considerations resulting in the identification of 4b and 3d, a hepatoselective HMG-CoA reductase inhibitor with excellent acute and chronic efficacy in a vitro model.

Comments

© Chemistry & Biology Interface is the property of Indian Society of Chemists & Biologists. Original published version available here.

First Page

172

Last Page

185

Publication Title

Chemistry & Biology Interface

Academic Level

faculty

Mentor/PI Department

Immunology and Microbiology

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