School of Medicine Publications and Presentations

Document Type


Publication Date

Summer 2024


Reactive oxygen species (ROS) play significant roles in various pathological diseases due to their ability to induce oxidative stress and damage cellular components. It is known that some amount of ROS is essential in normal cell function as signaling molecules involved in various physiological processes. However, there is a noted upregulation of ROS in neoplastic cells. Despite this, cancer cells have adaptations such as efflux pumps and transcription factors that allow for their viability in oxidative conditions. Through several mechanisms, ROS can initiate programmed cell death (PCD), potentially serving as a cancer therapy. Strategies aimed at manipulating ROS levels to selectively induce cytotoxicity in cancer cells while sparing normal cells through coadministration with chemotherapies are being explored as potential treatments in cancer therapy. Additionally, targeting antioxidant defense mechanisms in cancer cells to disrupt redox homeostasis and sensitize these cells to ROS-mediated cell death is an area of active investigation.

Academic Level

medical student

Mentor/PI Department

Medical Education

Available for download on Thursday, July 01, 2027