Document Type

Article

Publication Date

2019

Abstract

A series of 2,4-diaminopyrimidine-5-carbonitrile and N-(2-amino-5-cyanopyrimidin-4-yl) benzamide derivatives (5–14) were synthesized and their chemical structures were confirmed by 1 H, 13C NMR and mass spectral data. Anticancer activity of all the synthesized compounds were evaluated for in vitro cytotoxic activity against a panel of four human cancer cell lines i.e., human breast (MCF-7,), cervical cancer (C33A), oral (KB) and prostrate (DU-145). All the examined compounds, demonstrated potent to moderate anticancer activity. Among all the synthesized compounds, 6 and 11 were exhibited more potent activity. Docking studies for 6 and 11 into EGFR active site was carried out to investigate their potential binding modes. Therefore, compounds 6 and 11 can be considered as fascinating candidates for further expansion of more potent anticancer agents.

Comments

© Chemistry & Biology Interface is the property of Indian Society of Chemists & Biologists. Original published version available here.

First Page

148

Last Page

156

Publication Title

Chemistry & Biology Interface

Academic Level

faculty

Mentor/PI Department

Immunology and Microbiology

Included in

Diseases Commons

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