School of Medicine Publications and Presentations
Document Type
Article
Publication Date
2024
Abstract
Background: Peripartum cardiomyopathy (PPCM) presents a significant global health challenge, contributing substantially to maternal morbidity and mortality worldwide. Despite ongoing research efforts, the multifaceted nature of PPCM, encompassing genetic, environmental, and clinical factors, necessitates a comprehensive understanding to improve patient outcomes effectively.
Aims: This systematic review aims to synthesise current knowledge on PPCM aetiology, risk factors, diagnosis, therapeutic interventions, and prognostic indicators, highlighting recent advancements and potential avenues for future research and clinical management. By addressing key aspects such as genetic predispositions, environmental influences, diagnostic strategies, therapeutic modalities, and global disparities, this review seeks to provide insights that can inform interdisciplinary approaches and ultimately enhance the care and outcomes of affected patients on a global scale.
Methodology: Narrative, qualitative systematic review of current literature.
Results: This systematic review delved into the multifaceted landscape of PPCM, revealing genetic, environmental, and clinical intricacies. Key findings included the identification of TTN truncating mutations as a significant genetic predisposition, prompting personalised medical interventions. Environmental factors, such as PM2.5 exposure, intersected with clinical dynamics, highlighting the need for interdisciplinary cooperation in healthcare and environmental policy. Additionally, studies emphasised the importance of timely diagnosis, global disparities in PPCM incidence, and the potential for personalised treatments like bromocriptine and targeted genetic therapies.
Conclusion: This review illuminated the complexity of peripartum cardiomyopathy and provides a roadmap for future research and clinical management, advocating for holistic approaches to improve patient outcomes
Recommended Citation
Ganiyu, S., Lawal, T. A., & Petrie, S. (2024). Peripartum Cardiomyopathy; Understanding And Improving Outcomes-A Systematic Review. Journal of Cardiovascular Disease Research, 15(6), 1106–1132. https://doi.org/10.48047/jcdr.2024.15.06.109
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 3.0 License.
First Page
1106
Last Page
1132
Publication Title
Journal of Cardiovascular Disease Research
DOI
https://doi.org/10.48047/jcdr.2024.15.06.109
Academic Level
resident
Mentor/PI Department
Internal Medicine
Comments
The articles in Journal of Cardiovascular Disease Research are open access articles licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc-sa/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.