School of Medicine Publications and Presentations

Phosphodiesterase Inhibitors in Cerebrovascular Perfusion and Pulsatility

Document Type

Editorial

Publication Date

7-4-2024

Abstract

Cerebral small vessel disease are microvascular pathological lesions frequently observed on brain magnetic resonance imaging scans of elderly individuals.1 Current strategies to prevent and treat cerebral small vessel disease include addressing modifiable risk factors such as high blood pressure. Epidemiological data and clinical trials have demonstrated the benefits of treating blood pressure to prevent and reduce the progression of cerebral small vessel disease, especially white matter hyperintensities.2,3 However, therapy targeting mechanisms involved in cerebral small vessel disease is needed as individuals with treated and controlled hypertension still experience progression of white matter hyperintensities.4,5

Comments

© 2024 American Heart Association, Inc.

Publication Title

Circulation Research

DOI

https://doi.org/10.1161/CIRCRESAHA.124.324954

Academic Level

faculty

Mentor/PI Department

Neuroscience

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