School of Medicine Publications and Presentations

Document Type

Article

Publication Date

1-15-2025

Abstract

Background

Although combat-deployed soldiers are at a high risk for developing trauma-related psychopathology, most will remain resilient for the duration and aftermath of their deployment tour. The neural basis of this type of resilience is largely unknown, and few longitudinal studies exist on neural adaptation to combat in resilient individuals for whom a pre-exposure measurement was collected. Here, we delineate changes in the architecture of functional brain networks from pre- to post-combat in psychopathology-free, resilient participants.

Methods

Tier 1 infantry recruits (n=50) participated in this longitudinal functional MRI (fMRI) study, along with a comparison group of university students (n=50). Changes in within- and between-network functional connectivity as a function of exposure group were analyzed.

Results

Significant group-by-time interactions manifested in the default mode, cognitive control, and ventral attention networks: significant increases from baseline, in both within- and between-network connectivity, were noted post-deployment in soldiers only.

Conclusions

These results indicate global changes in brain functional architecture in resilient combat-deployed participants relative to age-matched students, suggesting that neural adaptation may support resilience to combat exposure. Clinicaltrials.gov Identifier: NCT04651192; https://clinicaltrials.gov/study/NCT04651192

Comments

Original published version available at https://doi.org/10.1016/j.bpsc.2024.12.017

Publication Title

Biological Psychiatry: Cognitive Neuroscience and Neuroimaging

DOI

https://doi.org/10.1016/j.bpsc.2024.12.017

Academic Level

faculty

Mentor/PI Department

Office of Human Genetics

Available for download on Thursday, January 15, 2026

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