
School of Medicine Publications and Presentations
Document Type
Article
Publication Date
11-19-2024
Abstract
Autophagy is an intrinsic breakdown system that recycles organelles and macromolecules, which influences metabolic pathways, differentiation, and thereby cell survival. Oral health is an essential component of integrated well-being, and it is critical for developing therapeutic interventions to understand the molecular mechanisms underlying the maintenance of oral homeostasis. However, because of the complex dynamic relationship between autophagy and oral health, associated treatment modalities have not yet been well elucidated. Determining how autophagy affects oral health at the molecular level may enhance the understanding of prevention and treatment of targeted oral diseases. At the molecular level, hard and soft oral tissues develop because of complex interactions between epithelial and mesenchymal cells. Aging contributes to the progression of various oral disorders including periodontitis, oral cancer, and periapical lesions during aging. Autophagy levels decrease with age, thus indicating a possible association between autophagy and oral disorders with aging. In this review, we critically review various aspects of autophagy and their significance in the context of various oral diseases including oral cancer, periapical lesions, periodontal conditions, and candidiasis. A better understanding of autophagy and its underlying mechanisms can guide us to develop new preventative and therapeutic strategies for the management of oral diseases.
Recommended Citation
Rahman, M. A., Shaikh, M. H., Gupta, R. D., Siddika, N., Shaikh, M. S., Zafar, M. S., Kim, B., & Hoque Apu, E. (2024). Advancements in Autophagy Modulation for the Management of Oral Disease: A Focus on Drug Targets and Therapeutics. Biomedicines, 12(11), 2645. https://doi.org/10.3390/biomedicines12112645
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Publication Title
Biomedicines
DOI
https://doi.org/10.3390/biomedicines12112645
Academic Level
faculty
Mentor/PI Department
Medical Education
Comments
© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).