
School of Medicine Publications and Presentations
Document Type
Article
Publication Date
12-1-2015
Abstract
The impact of statin treatment on the abnormal plasma lipidome of mixed dyslipidemic patients with metabolic syndrome (MetS), a group at increased risk of developing diabetes, was evaluated. Insulin-resistant hypertriglyceridemic hypertensive obese males (n = 12) displaying MetS were treated with pitavastatin (4 mg/day) for 180 days; healthy normolipidemic age-matched nonobese males (n = 12) acted as controls. Statin treatment substantially normalized triglyceride ( ô 41%), remnant cholesterol ( ô 55%), and LDLcholesterol ( ô 39%), with minor effect on HDL-cholesterol (+4%). Lipidomic analysis, normalized to nonHDL-cholesterol in order to probe statin-induced differences in molecular composition independently of reduction in plasma cholesterol, revealed increment in 132 of 138 lipid species that were subnormal at baseline and significantly shifted toward the control group on statin treatment. Increment in alkyland alkenylphospholipids (plasmalogens) was prominent, and consistent with significant statin-induced increase in plasma polyunsaturated fatty acid levels. Comparison of the statin-mediated lipidomic changes in MetS with the abnormal plasma lipidomic profile characteristic of prediabetes and T2D in the Australian Diabetes, Obesity, and Lifestyle Study and San Antonio Family Heart Study cohorts by hypergeometric analysis revealed a significant shift toward the lipid profile of controls, indicative of a marked trend toward a normolipidemic phenotype. Pitavastatin attenuated the abnormal plasma lipidome of MetS patients typical of prediabetes and T2D.
Recommended Citation
Meikle, P. J., Wong, G., Tan, R., Giral, P., Robillard, P., Orsoni, A., ... & Chapman, M. J. (2015). Statin action favors normalization of the plasma lipidome in the atherogenic mixed dyslipidemia of MetS: potential relevance to statin-associated dysglycemia. Journal of lipid research, 56(12), 2381-2392. https://doi.org/10.1194/jlr.P061143
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
First Page
2381
Last Page
2392
Publication Title
Journal of Lipid Research
DOI
10.1194/jlr.P061143
Academic Level
faculty
Mentor/PI Department
Office of Human Genetics
Comments
http://creativecommons.org/licenses/by/4.0/