
School of Medicine Publications and Presentations
Genomic studies of human populations: Resequencing approaches to the identification of human quantitative loci
Document Type
Book Chapter
Publication Date
1-1-2015
Abstract
In this chapter, we explore resequencing approaches to identify the quantitative loci in human populations. We will discuss why sequencing studies are optimal for variant discovery for common complex disease and how we go about localizing and identifying these causal variants. There are several different sequencing applications available to us today ranging from RNA sequencing to targeted genomic sequencing and extending to whole genome sequencing. We explore each of these applications and their individual utilities. Further, we explore studies of complex pedigrees compared to unrelated individuals, the two most common study designs used for human complex disease.
Recommended Citation
Curran, J.E., Bellis, C., Almasy, L., Blangero, J. (2015). Genomic Studies of Human Populations: Resequencing Approaches to the Identification of Human Quantitative Loci. In: Duggirala, R., Almasy, L., Williams-Blangero, S., Paul, S., Kole, C. (eds) Genome Mapping and Genomics in Human and Non-Human Primates. Genome Mapping and Genomics in Animals, vol 5. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-46306-2_16
First Page
289
Last Page
299
Publication Title
Genome Mapping and Genomics in Human and Non-Human Primates
DOI
10.1007/978-3-662-46306-2_16
Academic Level
faculty
Mentor/PI Department
Office of Human Genetics
Comments
© 2015 Springer-Verlag Berlin Heidelberg
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