
School of Medicine Publications and Presentations
Linkage mapping: Localizing the genes that shape human variation
Document Type
Book Chapter
Publication Date
1-1-2015
Abstract
Linkage analysis has a long and successful history as a tool for localizing genes that shape human variation. This chapter provides a brief history of linkage analysis and an overview of linkage analysis methods used to map genes in human and nonhuman primate samples. The concepts behind linkage analysis are reviewed as basic approaches to Mendelian penetrance model-based, concordant and discordant sibling pair, and quantitative trait linkage. Examples of the successful application of these techniques in human and nonhuman primate studies are provided. Special challenges for linkage analysis in nonhuman primates and the role of linkage analysis in the whole genome sequence era are also discussed.
Recommended Citation
Almasy, L., Kos, M.Z., Blangero, J. (2015). Linkage Mapping: Localizing the Genes That Shape Human Variation. In: Duggirala, R., Almasy, L., Williams-Blangero, S., Paul, S., Kole, C. (eds) Genome Mapping and Genomics in Human and Non-Human Primates. Genome Mapping and Genomics in Animals, vol 5. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-46306-2_3
First Page
33
Last Page
52
Publication Title
Genome Mapping and Genomics in Human and Non-Human Primates
DOI
10.1007/978-3-662-46306-2_3
Academic Level
faculty
Mentor/PI Department
Office of Human Genetics
Comments
© 2015 Springer-Verlag Berlin Heidelberg
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