School of Medicine Publications and Presentations

Linkage mapping: Localizing the genes that shape human variation

Document Type

Book Chapter

Publication Date

1-1-2015

Abstract

Linkage analysis has a long and successful history as a tool for localizing genes that shape human variation. This chapter provides a brief history of linkage analysis and an overview of linkage analysis methods used to map genes in human and nonhuman primate samples. The concepts behind linkage analysis are reviewed as basic approaches to Mendelian penetrance model-based, concordant and discordant sibling pair, and quantitative trait linkage. Examples of the successful application of these techniques in human and nonhuman primate studies are provided. Special challenges for linkage analysis in nonhuman primates and the role of linkage analysis in the whole genome sequence era are also discussed.

Comments

© 2015 Springer-Verlag Berlin Heidelberg

https://rdcu.be/d7GMf

First Page

33

Last Page

52

Publication Title

Genome Mapping and Genomics in Human and Non-Human Primates

DOI

10.1007/978-3-662-46306-2_3

Academic Level

faculty

Mentor/PI Department

Office of Human Genetics

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